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Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

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dc.contributor.author Chagas, Manoel Pinheiro
dc.contributor.author Santos, Josué Carinhanha Caldas
dc.contributor.author Santos, Eduardo Batista Guimarães Nunes dos
dc.contributor.author Oliveira, Tiago Dantas de
dc.contributor.author Korn, Mauro
dc.contributor.author Rodriguez, Martius Vicente Rodriguez y
dc.contributor.author Endre, Ricardo B.
dc.date.accessioned 2020-07-20T00:56:05Z
dc.date.available 2020-07-20T00:56:05Z
dc.date.issued 2009
dc.identifier.citation CHAGAS, Manoel P. et al. Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations. Journal of the Brazilian Chemical Society, v. 20, n. 9, p. 1646-1652, 2009.
dc.identifier.uri http://hdl.handle.net/123456789/1850
dc.description.abstract Um procedimento espectrofotométrico de análise em fluxo foi desenvolvido para determinação de Captopril (CPT) e N-acetil-L-cisteína (NAC) em formulações farmacêuticas baseado na reação com radical iminoquinona produzido pela oxidação de N,N-dimetil-p-fenilenodiamina (DMPD) em meio ácido. A ordem de adição de reagentes foi avaliada e os parâmetros analíticos foram otimizados. As faixas lineares de concentração foram de 2,5-90 e de 5,0-50 mg L-1 para CPT e NAC, respectivamente. Os limites de detecção (3σ) foram calculados em 0,22 e 1,8 mg L-1 e desvios padrão relativos (N = 10) foram inferiores que 1,0 e 2,1% para CPT e NAC, respectivamente. O procedimento foi empregado para a determinação de CPT e NAC em diversas formulações farmacêuticas e os resultados concordaram com os obtidos pelos métodos de referência para 95% de confiabilidade aplicando teste-t pareado. ____________________________________________________________________________________.
dc.description.abstract ABSTRACT - A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents addition order was evaluated and analytical parameters were optimized. The linear concentrations ranges were 2.5-90 and 5.0-50 mg L-1 for CPT and NAC, respectively. Limits of detection (3σ) were calculated at 0.22 and 1.8 mg L-1 and the relative standard deviation (N = 10) were lower than 1.0 and 2.1% for CPT and NAC, respectively. The procedure was employed for CPT and NAC determination in diverse pharmaceutical formulations and by applying paired t-test the results were in agreement with those obtained by reference methods for 95% confidence level.
dc.format.extent 7 p. : il.
dc.language.iso eng
dc.rights Open Access
dc.title Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
dc.type Artigo
dc.subject.keyword Análise química
dc.subject.keyword Formulação farmacêutica
dc.subject.keyword Captopril


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