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Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells

Show simple item record Oliveira, Felipe Leite de Chammas, Roger Ricon, Lauremília Fermino, Marise Lopes Bernardes, Emerson Soares Hsu, Daniel Kaiyuan Liu, Fu-Tong Borojevic, Radovan El-Cheikh, Márcia Cury Lamas, Marcelo Einicker Leite Júnior, Maurilo de Nazaré de Lima Morales, Marcelo Marcos Vieyra, Adalberto Ramon Fraga, Sandra Regina Gomes Monteiro, Tânia Maria Araújo, Thiago de Oliveira Silva, Viviane Fernandes da Gomes, Eduardo Rodrigues Bernardes, Américo Tristão 2020-07-20T00:25:50Z 2020-07-20T00:25:50Z 2009
dc.identifier.citation OLIVEIRA, Felipe L. et al. Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells. Glycobiology, v. 19, p. 1248-1258, 2009.
dc.description.abstract Extracellular galectin-3 participates in the control of B2 lymphocytemigration and adhesion and of their differentiation into plasma cells. Here, we analyzed the role of galectin- 3 in B1-cell physiology and the balance between B1a and B1b lymphocytes in the peritoneal cavity. In galectin-3−/− mice, the total number of B1a lymphocytes was lower, while B1b lymphocyte number was higher as compared to wild-type mice. The differentiation of B1a cells into plasma cells was associated with their abnormal adhesion and location on the mesentery. The B220 and CD43, constitutively expressed by B1 lymphocytes, were respectively up- and downregulated in galectin-3−/− mice. Mononuclear cells were strongly adhered to the mesenteric membranes of both CD43−/− and galectin-3−/− mice, but in contrast to CD43−/− mice, the accumulation of B1 cells in peritoneal membranes in galectin- 3−/− mice was accompanied by their functional differentiation into plasma cells.We have shown that in the absence of galectin-3, B1-cell differentiation into plasma cells is favored and the dynamic equilibrium of B1-cell populations in the peritoneum is maintained through a compensatory increase in B1b lymphocytes.
dc.format.extent 11 p. : il.
dc.language.iso eng
dc.rights Open Access
dc.title Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells
dc.type Artigo
dc.subject.keyword Biologia celular : célula de plasma
dc.subject.keyword Cavidade peritonial
dc.subject.keyword Plasmócito

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